| ncRNA name | PAI-1 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | primary human retinal pericytes |
| Methods | siRNA transfection, flow cytometry |
| Expression pattern | associated |
| Functional description | Retinal pericyte loss and neovascularization are characteristic features of diabetic retinopathy. PAI-1 siRNA significantly inhibited pericyte apoptosis by inhibiting the overexpression of PAI-1, which is induced by high glucose. |
| PubMed ID | 26391252 |
| Year | 2015 |
| Title | Gemigliptin, a dipeptidyl peptidase-4 inhibitor, inhibits retinal pericyte injury in db/db mice and retinal neovascularization in mice with ischemic retinopathy. |
| Drug-related ncRNA | NO |
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